January 27, 2025
January 6, 2016
Use of selective HDACi to improve antibody blockad...
Description: Immunotherapies, such as CTLA-4 or PD-1 inhibitors, have revolutionized the treatment of metastatic melanoma patients. However, a key challenge to optimize the...
January 6, 2016
Regulation of the response to targeted inhibitors ...
Description: Melanoma of the uveal tract (a region of the eye) is the most common ocular malignancy in adults and accounts for 5% of all melanomas. According to N...
January 6, 2016
The role of the Anaphase-Promoting Complex in huma...
Description: Mutations in a small number of genes are found in a large fraction of human melanomas. For instance, so-called “driver” mutations in the “famous” melan...
January 6, 2016
Epigenetic effectors of tumor response to immune c...
Description: Treatment of advanced melanoma with immunotherapy agents shows striking responses in some patients, however overall responses are low. In addition, a significa...
January 6, 2016
Mechanism of metastasis in a less common molecular...
Description: The major cause of death in uveal melanoma patients is the spread or metastasis of the cancer to other vital organs such as the liver. Although most ...
